Substituted 1,2,4-Triazoles as Novel and Selective Inhibitors of Leukotriene Biosynthesis Targeting 5-Lipoxygenase-Activating Protein

[Image: see text] 5-Lipoxygenase-activating protein (FLAP) is a regulator of cellular leukotriene biosynthesis, which governs the transfer of arachidonic acid (AA) to 5-lipoxygenase for efficient metabolism. Here, the synthesis and FLAP-antagonistic potential of fast synthetically accessible 1,2,4-t...

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Detalles Bibliográficos
Autores principales: Olğaç, Abdurrahman, Çapan, İrfan, Dahlke, Philipp, Jordan, Paul M., Werz, Oliver, Banoglu, Erden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468765/
https://www.ncbi.nlm.nih.gov/pubmed/37663492
http://dx.doi.org/10.1021/acsomega.3c03682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468765/
https://www.ncbi.nlm.nih.gov/pubmed/37663492
http://dx.doi.org/10.1021/acsomega.3c03682

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