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Targeted evolution of adeno-associated virus capsids for systemic transgene delivery to microglia and tissue-resident macrophages
Tissue macrophages, including microglia, are notoriously resistant to genetic manipulation. Here, we report the creation of Adeno-associated viruses (AAV) variants that efficiently and widely transduce microglia and tissue macrophages in vivo following intravenous delivery, with transgene expression...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469016/ https://www.ncbi.nlm.nih.gov/pubmed/37603759 http://dx.doi.org/10.1073/pnas.2302997120 |