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Targeted evolution of adeno-associated virus capsids for systemic transgene delivery to microglia and tissue-resident macrophages

Tissue macrophages, including microglia, are notoriously resistant to genetic manipulation. Here, we report the creation of Adeno-associated viruses (AAV) variants that efficiently and widely transduce microglia and tissue macrophages in vivo following intravenous delivery, with transgene expression...

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Detalles Bibliográficos
Autores principales:	Young, Adam, Neumann, Bjoern, Segel, Michael, Chen, Civia Zi-Yu, Tourlomousis, Panagiotis, Franklin, Robin J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469016/ https://www.ncbi.nlm.nih.gov/pubmed/37603759 http://dx.doi.org/10.1073/pnas.2302997120

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