Cargando…
The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution
The anemias of myelodysplastic syndrome (MDS) and Diamond Blackfan anemia (DBA) are generally macrocytic and always reflect ineffective erythropoiesis yet result from diverse genetic mutations. To delineate shared mechanisms that lead to cell death, we studied the fate of single erythroid marrow cel...
Autores principales: | Doty, Raymond T., Lausted, Christopher G., Munday, Adam D., Yang, Zhantao, Yan, Xiaowei, Meng, Changting, Tian, Qiang, Abkowitz, Janis L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Hematology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469080/ https://www.ncbi.nlm.nih.gov/pubmed/37352261 http://dx.doi.org/10.1182/bloodadvances.2023010382 |
Ejemplares similares
-
Erythroferrone exacerbates iron overload and ineffective extramedullary erythropoiesis in a mouse model of β-thalassemia
por: Olivera, Joseph, et al.
Publicado: (2023) -
Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis
por: Narla, Anupama, et al.
Publicado: (2011) -
Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeleton
por: Szpak, Dorota, et al.
Publicado: (2023) -
ATG4A regulates human erythroid maturation and mitochondrial clearance
por: Stolla, Massiel Chavez, et al.
Publicado: (2022) -
Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis
por: Liang, Raymond, et al.
Publicado: (2023)