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DANGER analysis: risk-averse on/off-target assessment for CRISPR editing without a reference genome
MOTIVATION: The CRISPR-Cas9 system has successfully achieved site-specific gene editing in organisms ranging from humans to bacteria. The technology efficiently generates mutants, allowing for phenotypic analysis of the on-target gene. However, some conventional studies did not investigate whether d...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469126/ https://www.ncbi.nlm.nih.gov/pubmed/37661945 http://dx.doi.org/10.1093/bioadv/vbad114 |