Calmodulin mutations affecting Gly114 impair binding to the Na(V)1.5 IQ-domain

Missense variants in CALM genes encoding the Ca(2+)-binding protein calmodulin (CaM) cause severe cardiac arrhythmias. The disease mechanisms have been attributed to dysregulation of RyR2, for Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) and/or Ca(V)1.2, for Long-QT Syndrome (LQTS)....

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Detalles Bibliográficos
Autores principales: Brohus, Malene, Busuioc, Ana-Octavia, Wimmer, Reinhard, Nyegaard, Mette, Overgaard, Michael Toft
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469309/
https://www.ncbi.nlm.nih.gov/pubmed/37663247
http://dx.doi.org/10.3389/fphar.2023.1210140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469309/
https://www.ncbi.nlm.nih.gov/pubmed/37663247
http://dx.doi.org/10.3389/fphar.2023.1210140

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