Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits

Genetic association studies have identified hundreds of independent signals associated with type 2 diabetes (T2D) and related traits. Despite these successes, the identification of specific causal variants underlying a genetic association signal remains challenging. In this study, we describe a deep...

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Detalles Bibliográficos
Autores principales: Hudaiberdiev, Sanjarbek, Taylor, D. Leland, Song, Wei, Narisu, Narisu, Bhuiyan, Redwan M., Taylor, Henry J., Tang, Xuming, Yan, Tingfen, Swift, Amy J., Bonnycastle, Lori L., Consortium, DIAMANTE, Chen, Shuibing, Stitzel, Michael L., Erdos, Michael R., Ovcharenko, Ivan, Collins, Francis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469333/
https://www.ncbi.nlm.nih.gov/pubmed/37603758
http://dx.doi.org/10.1073/pnas.2206612120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469333/
https://www.ncbi.nlm.nih.gov/pubmed/37603758
http://dx.doi.org/10.1073/pnas.2206612120

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