A DNA adenine demethylase impairs PRC2-mediated repression of genes marked by a specific chromatin signature

BACKGROUND: The Fe (II)- and α-ketoglutarate-dependent AlkB family dioxygenases are implicated in nucleotide demethylation. AlkB homolog1 (ALKBH1) is shown to demethylate DNA adenine methylation (6mA) preferentially from single-stranded or unpaired DNA, while its demethylase activity and function in...

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Detalles Bibliográficos
Autores principales: Jia, Qingxiao, Zhang, Xinran, Liu, Qian, Li, Junjie, Wang, Wentao, Ma, Xuan, Zhu, Bo, Li, Sheng, Gong, Shicheng, Tian, Jingjing, Yuan, Meng, Zhao, Yu, Zhou, Dao-Xiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469495/
https://www.ncbi.nlm.nih.gov/pubmed/37649077
http://dx.doi.org/10.1186/s13059-023-03042-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469495/
https://www.ncbi.nlm.nih.gov/pubmed/37649077
http://dx.doi.org/10.1186/s13059-023-03042-4

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