Impaired tissue homing by the Ikzf3(N159S) variant is mediated by interfering with Ikaros function

AIOLOS, encoded by IKZF3, is a member of the IKZF family of proteins that plays an important role in regulating late B-cell differentiation. Human individuals heterozygous for the AIOLOS p.N160S variant displayed impaired humoral immune responses as well as impaired B and T cell development. We have...

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Detalles Bibliográficos
Autores principales: Chang, Jingjie, Yamashita, Motoi, Padhi, Aditya K., Zhang, Kam Y. J., Taniuchi, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469740/
https://www.ncbi.nlm.nih.gov/pubmed/37662955
http://dx.doi.org/10.3389/fimmu.2023.1239779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469740/
https://www.ncbi.nlm.nih.gov/pubmed/37662955
http://dx.doi.org/10.3389/fimmu.2023.1239779

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