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Impaired tissue homing by the Ikzf3(N159S) variant is mediated by interfering with Ikaros function
AIOLOS, encoded by IKZF3, is a member of the IKZF family of proteins that plays an important role in regulating late B-cell differentiation. Human individuals heterozygous for the AIOLOS p.N160S variant displayed impaired humoral immune responses as well as impaired B and T cell development. We have...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469740/ https://www.ncbi.nlm.nih.gov/pubmed/37662955 http://dx.doi.org/10.3389/fimmu.2023.1239779 |