A polygenic risk score for Alzheimer’s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.

INTRODUCTION: Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for an outcome. METHODS: We used summary statistics from five GWASs of AD to construct PRSs in 4,189 diverse Hispanics/Latinos (mean age 63 years) from the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INC...

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Detalles Bibliográficos
Autores principales: Sofer, Tamar, Kurniansyah, Nuzulul, Granot-Hershkovitz, Einat, Goodman, Matthew O., Tarraf, Wassim, Broce, Iris, Lipton, Richard B., Daviglus, Martha, Lamar, Melissa, Wassertheil-Smoller, Sylvia, Cai, Jianwen, DeCarli, Charles S., Gonzalez, Hector M., Fornage, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469805/
https://www.ncbi.nlm.nih.gov/pubmed/37649099
http://dx.doi.org/10.1186/s13195-023-01298-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469805/
https://www.ncbi.nlm.nih.gov/pubmed/37649099
http://dx.doi.org/10.1186/s13195-023-01298-3

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