A novel UHPLC‒MS/MS method for quantitative analysis of zanubrutinib in rat plasma: application to an in vivo interaction study between zanubrutinib and triazole antifungal

BACKGROUND: This study establishes a UHPLC‒MS/MS method for the detection of zanubrutinib and explores its interaction with fluconazole and isavuconazole in rats. METHODS: A protein precipitation method using acetonitrile was used to prepare plasma samples using ibrutinib as an internal standard. Ch...

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Detalles Bibliográficos
Autores principales: Tang, Peng-fei, Bao, Su-su, Xiao, Zhong-xiang, Xie, Wei-fei, Wu, Xue-meng, Ge, Hong-lei, Shao, Chuan-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469817/
https://www.ncbi.nlm.nih.gov/pubmed/37649082
http://dx.doi.org/10.1186/s13065-023-01017-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469817/
https://www.ncbi.nlm.nih.gov/pubmed/37649082
http://dx.doi.org/10.1186/s13065-023-01017-x

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