Metabolic signature and proteasome activity controls synovial migration of CDC42(hi) CD14(+) cells in rheumatoid arthritis

OBJECTIVE: Activation of Rho-GTPases in macrophages causes inflammation and severe arthritis in mice. In this study, we explore if Rho-GTPases define the joint destination of pathogenic leukocytes, the mechanism by which they perpetuate rheumatoid arthritis (RA), and how JAK inhibition mitigates the...

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Detalles Bibliográficos
Autores principales: Malmhäll-Bah, Eric, Andersson, Karin M.E., Erlandsson, Malin C., Silfverswärd, Sofia T., Pullerits, Rille, Bokarewa, Maria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469903/
https://www.ncbi.nlm.nih.gov/pubmed/37662900
http://dx.doi.org/10.3389/fimmu.2023.1187093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469903/
https://www.ncbi.nlm.nih.gov/pubmed/37662900
http://dx.doi.org/10.3389/fimmu.2023.1187093

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