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Metabolic signature and proteasome activity controls synovial migration of CDC42(hi) CD14(+) cells in rheumatoid arthritis
OBJECTIVE: Activation of Rho-GTPases in macrophages causes inflammation and severe arthritis in mice. In this study, we explore if Rho-GTPases define the joint destination of pathogenic leukocytes, the mechanism by which they perpetuate rheumatoid arthritis (RA), and how JAK inhibition mitigates the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469903/ https://www.ncbi.nlm.nih.gov/pubmed/37662900 http://dx.doi.org/10.3389/fimmu.2023.1187093 |