N-glycosylation is a potent regulator of prion protein neurotoxicity

The C-terminal domain of the cellular prion protein (PrP(C)) contains two N-linked glycosylation sites, the occupancy of which impacts disease pathology. In this study, we demonstrate that glycans at these sites are required to maintain an intramolecular interaction with the N-terminal domain, media...

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Detalles Bibliográficos
Autores principales: Schilling, Kevin M., Jorwal, Pooja, Ubilla-Rodriguez, Natalia C., Assafa, Tufa E., Gatdula, Jean R.P., Vultaggio, Janelle S., Harris, David A., Millhauser, Glenn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469999/
https://www.ncbi.nlm.nih.gov/pubmed/37507020
http://dx.doi.org/10.1016/j.jbc.2023.105101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469999/
https://www.ncbi.nlm.nih.gov/pubmed/37507020
http://dx.doi.org/10.1016/j.jbc.2023.105101

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