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N-glycosylation is a potent regulator of prion protein neurotoxicity
The C-terminal domain of the cellular prion protein (PrP(C)) contains two N-linked glycosylation sites, the occupancy of which impacts disease pathology. In this study, we demonstrate that glycans at these sites are required to maintain an intramolecular interaction with the N-terminal domain, media...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469999/ https://www.ncbi.nlm.nih.gov/pubmed/37507020 http://dx.doi.org/10.1016/j.jbc.2023.105101 |