Intermolecular electron transfer in radical SAM enzymes as a new paradigm for reductive activation

Radical S-adenosyl-L-methionine (rSAM) enzymes bind one or more Fe-S clusters and catalyze transformations that produce complex and structurally diverse natural products. One of the clusters, a 4Fe-4S cluster, binds and reductively cleaves SAM to generate the 5′-deoxyadenosyl radical, which initiate...

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Detalles Bibliográficos
Autores principales: Eastman, Karsten A.S., Jochimsen, Andrew S., Bandarian, Vahe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470005/
https://www.ncbi.nlm.nih.gov/pubmed/37460016
http://dx.doi.org/10.1016/j.jbc.2023.105058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470005/
https://www.ncbi.nlm.nih.gov/pubmed/37460016
http://dx.doi.org/10.1016/j.jbc.2023.105058

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