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Intermolecular electron transfer in radical SAM enzymes as a new paradigm for reductive activation
Radical S-adenosyl-L-methionine (rSAM) enzymes bind one or more Fe-S clusters and catalyze transformations that produce complex and structurally diverse natural products. One of the clusters, a 4Fe-4S cluster, binds and reductively cleaves SAM to generate the 5′-deoxyadenosyl radical, which initiate...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470005/ https://www.ncbi.nlm.nih.gov/pubmed/37460016 http://dx.doi.org/10.1016/j.jbc.2023.105058 |