Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow

BACKGROUND: Therapeutic cancer vaccination against mutant calreticulin (CALR) in patients with CALR-mutant (CALRmut) myeloproliferative neoplasms (MPN) induces strong T-cell responses against mutant CALR yet fails to demonstrate clinical activity. Infiltration of tumor specific T cells into the tumo...

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Detalles Bibliográficos
Autores principales: Holmström, Morten Orebo, Andersen, Morten, Traynor, Sofie, Ahmad, Shamaila Munir, Lisle, Thomas Landkildehus, Handlos Grauslund, Jacob, Skov, Vibe, Kjær, Lasse, Ottesen, Johnny T., Gjerstorff, Morten Frier, Hasselbalch, Hans Carl, Andersen, Mads Hald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470021/
https://www.ncbi.nlm.nih.gov/pubmed/37662956
http://dx.doi.org/10.3389/fimmu.2023.1240678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470021/
https://www.ncbi.nlm.nih.gov/pubmed/37662956
http://dx.doi.org/10.3389/fimmu.2023.1240678

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