Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil

Folate-mediated one-carbon metabolism (FOCM) is crucial in sustaining rapid proliferation and survival of cancer cells. The folate cycle depends on a series of key cellular enzymes, including aldehyde dehydrogenase 1 family member L2 (ALDH1L2) that is usually overexpressed in cancer cells, but the r...

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Detalles Bibliográficos
Autores principales: Li, Chaoqun, Teng, Peng, Sun, Shengbai, Cui, Kaisa, Yao, Surui, Fei, Bojian, Ling, Feng, Huang, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470206/
https://www.ncbi.nlm.nih.gov/pubmed/37507016
http://dx.doi.org/10.1016/j.jbc.2023.105090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470206/
https://www.ncbi.nlm.nih.gov/pubmed/37507016
http://dx.doi.org/10.1016/j.jbc.2023.105090

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