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Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain
In eukaryotic cells, the introns are excised from pre-mRNA by the spliceosome. These introns typically have a lariat configuration due to the 2′-5′ phosphodiester bond between an internal branched residue and the 5′ terminus of the RNA. The only enzyme known to selectively hydrolyze the 2′-5′ linkag...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470207/ https://www.ncbi.nlm.nih.gov/pubmed/37507019 http://dx.doi.org/10.1016/j.jbc.2023.105100 |