Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain

In eukaryotic cells, the introns are excised from pre-mRNA by the spliceosome. These introns typically have a lariat configuration due to the 2′-5′ phosphodiester bond between an internal branched residue and the 5′ terminus of the RNA. The only enzyme known to selectively hydrolyze the 2′-5′ linkag...

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Detalles Bibliográficos
Autores principales: Clark, Nathaniel E., Katolik, Adam, Gallant, Pascal, Welch, Anastasia, Murphy, Eileen, Buerer, Luke, Schorl, Christoph, Naik, Nandita, Naik, Mandar T., Holloway, Stephen P., Cano, Kristin, Weintraub, Susan T., Howard, Katherine M., Hart, P. John, Jogl, Gerwald, Damha, Masad J., Fairbrother, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470207/
https://www.ncbi.nlm.nih.gov/pubmed/37507019
http://dx.doi.org/10.1016/j.jbc.2023.105100

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