Cargando…

Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model

BACKGROUND: Women are at greater risk of developing non-small cell lung cancer (NSCLC), yet the underlying causes remain unclear. METHODS: We performed whole genome scans in lung tumours of cRaf transgenic mice and identified miRNA, transcription factor and hormone receptor dependent gene regulation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhong, Shen, Borlak, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470261/ https://www.ncbi.nlm.nih.gov/pubmed/37625265 http://dx.doi.org/10.1016/j.ebiom.2023.104763

Ejemplares similares

Three distinct regions of cRaf kinase domain interact with membrane
por: Prakash, Priyanka, et al.
Publicado: (2019)

Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors
por: Chatelle, Claire V., et al.
Publicado: (2016)

Molecular Characterization of Lung Dysplasia Induced by c-Raf-1
por: Rohrbeck, Astrid, et al.
Publicado: (2009)

CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition
por: Noeparast, Amir, et al.
Publicado: (2019)

X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
por: Fadó, Rut, et al.
Publicado: (2013)

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho–Ser-621 in the C terminus of CRAF
por: Yuan, Jimin, et al.
Publicado: (2018)

Cancer Genomics Identifies Regulatory Gene Networks Associated with the Transition from Dysplasia to Advanced Lung Adenocarcinomas Induced by c-Raf-1
por: Rohrbeck, Astrid, et al.
Publicado: (2009)

A Cross-Platform Comparison of Genome-Wide Expression Changes of Laser Microdissected Lung Tissue of C-Raf Transgenic Mice Using 3′IVT and Exon Array
por: Londhe, Kishor Bapu, et al.
Publicado: (2012)

Correction: A Cross-Platform Comparison of Genome-Wide Expression Changes of Laser Microdissected Lung Tissue of C-Raf Transgenic Mice Using 3′IVT and Exon Array
por: Londhe, Kishor Bapu, et al.
Publicado: (2012)

A Cross-Platform Comparison of Affymetrix and Agilent Microarrays Reveals Discordant miRNA Expression in Lung Tumors of c-Raf Transgenic Mice
por: Del Vescovo, Valerio, et al.
Publicado: (2013)

Lung tumour growth kinetics in SPC-c-Raf-1-BB transgenic mice assessed by longitudinal in-vivo micro-CT quantification
por: Rodt, Thomas, et al.
Publicado: (2012)

Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network
por: Reymann, Susanne, et al.
Publicado: (2008)

Selective CRAF Inhibition Elicits Transactivation
por: Morgan, Charles W., et al.
Publicado: (2021)

Combined Micro-PET/Micro-CT Imaging of Lung Tumours in SPC-raf and SPC-myc Transgenic Mice
por: Rodt, Thomas, et al.
Publicado: (2012)

Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma
por: Ciribilli, Yari, et al.
Publicado: (2017)

Correction: Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma
por: Ciribilli, Yari, et al.
Publicado: (2018)

c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma
por: Ciribilli, Yari, et al.
Publicado: (2016)

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway
por: Liu, Shufeng, et al.
Publicado: (2015)

A MEK-independent role for CRAF in mitosis and tumor progression
por: Mielgo, Ainhoa, et al.
Publicado: (2011)

CRAF R391W is a melanoma driver oncogene
por: Atefi, Mohammad, et al.
Publicado: (2016)

Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas
por: Ciribilli, Yari, et al.
Publicado: (2015)

Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation
por: Cookis, Trinity, et al.
Publicado: (2021)

Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15
por: Hayes, Sebastian D., et al.
Publicado: (2012)

Kinase-independent role for CRAF-driving tumour radioresistance via CHK2
por: Advani, Sunil J., et al.
Publicado: (2015)

Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF
por: Pfeiffer, Verena, et al.
Publicado: (2018)

Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions
por: Fischer, Adrian, et al.
Publicado: (2016)

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
por: Heidorn, Sonja J., et al.
Publicado: (2010)

Oncogenic RAS drives the CRAF‐dependent extracellular vesicle uptake mechanism coupled with metastasis
por: Choi, Dongsic, et al.
Publicado: (2021)

Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma
por: Luan, Zhou, et al.
Publicado: (2014)

Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2
por: Wang, Penglei, et al.
Publicado: (2023)

Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades
por: Liu, Zhichao, et al.
Publicado: (2016)

Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
por: Bhargava, Ajay, et al.
Publicado: (2016)

Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice
por: Gentschev, Ivaylo, et al.
Publicado: (2005)

Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities
por: Parakh, Sagun, et al.
Publicado: (2021)

Sex-Differences in Aortic Stenosis: Mechanistic Insights and Clinical Implications
por: Matilla, Lara, et al.
Publicado: (2022)

A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations
por: Niitsu, Yoshiro, et al.
Publicado: (2020)

Implications of glutathione-S transferase P1 in MAPK signaling as a CRAF chaperone: In memory of Dr. Irving Listowsky
por: NIITSU, Yoshiro, et al.
Publicado: (2022)

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
por: Jin, Ting, et al.
Publicado: (2017)

Blocking C-Raf alleviated high-dose small-volume radiation-induced epithelial mesenchymal transition in mice lung
por: Hong, Zhen-Yu, et al.
Publicado: (2020)

Non‐canonical Raf‐1/p70S6K signalling in non–small‐cell lung cancer
por: Qiu, Zhixin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_abnbedphsb45tre0jrnr50vkmo