C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress

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The ALS/FTD-linked intronic hexanucleotide repeat expansion in the C9orf72 gene is aberrantly translated in the sense and antisense directions into dipeptide repeat proteins, among which poly proline-arginine (PR) displays the most aggressive neurotoxicity in-vitro and in-vivo. PR partitions to the...

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Detalles Bibliográficos
Autores principales: Cicardi, M.E., Hallgren, J.H., Mawrie, D., Krishnamurthy, K., Markandaiah, S.S., Nelson, A.T., Kankate, V., Anderson, E.N., Pasinelli, P., Pandey, U.B., Eischen, C.M., Trotti, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470315/
https://www.ncbi.nlm.nih.gov/pubmed/37664610
http://dx.doi.org/10.1016/j.isci.2023.107505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470315/
https://www.ncbi.nlm.nih.gov/pubmed/37664610
http://dx.doi.org/10.1016/j.isci.2023.107505

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