Glycoproteomics of a Single Protein: Revealing Tens of Thousands of Myozyme Glycoforms by Hybrid HPLC-MS Approaches

Characterization of highly glycosylated biopharma-ceuticals by mass spectrometry is challenging because of the huge chemical space of coexistent glycoforms present. Here, we report the use of an array of HPLC-mass spectrometry–based approaches at different structural levels of released glycan, glyco...

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Detalles Bibliográficos
Autores principales: Di Marco, Fiammetta, Blöchl, Constantin, Esser-Skala, Wolfgang, Schäpertöns, Veronika, Zhang, Tao, Wuhrer, Manfred, Sandra, Koen, Wohlschlager, Therese, Huber, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470421/
https://www.ncbi.nlm.nih.gov/pubmed/37478974
http://dx.doi.org/10.1016/j.mcpro.2023.100622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470421/
https://www.ncbi.nlm.nih.gov/pubmed/37478974
http://dx.doi.org/10.1016/j.mcpro.2023.100622

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