APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1

HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4(+) T lymphocytes and macrophages. Previous studies have demonstrated that the apolipoprotein B mRNA editing enzyme polypeptide-like 3 (APOBEC3, A3) family of proteins (at least A3D, A3F, A3G, and stable A3H haplotypes) cont...

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Detalles Bibliográficos
Autores principales: Ikeda, Terumasa, Shimizu, Ryo, Nasser, Hesham, Carpenter, Michael A., Cheng, Adam Z., Brown, William L., Sauter, Daniel, Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470580/
https://www.ncbi.nlm.nih.gov/pubmed/37555667
http://dx.doi.org/10.1128/mbio.00782-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470580/
https://www.ncbi.nlm.nih.gov/pubmed/37555667
http://dx.doi.org/10.1128/mbio.00782-23

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