A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

Coronaviruses (CoVs) encode nonstructural proteins 1–16 (nsps 1–16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis. RDV resistance mutations have been reported only in the nonstructural pro...

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Detalles Bibliográficos
Autores principales: Grimes, Samantha L., Choi, Young J., Banerjee, Anoosha, Small, Gabriel, Anderson-Daniels, Jordan, Gribble, Jennifer, Pruijssers, Andrea J., Agostini, Maria L., Abu-Shmais, Alexandra, Lu, Xiaotao, Darst, Seth A., Campbell, Elizabeth, Denison, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470589/
https://www.ncbi.nlm.nih.gov/pubmed/37338298
http://dx.doi.org/10.1128/mbio.01060-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470589/
https://www.ncbi.nlm.nih.gov/pubmed/37338298
http://dx.doi.org/10.1128/mbio.01060-23

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