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Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity

HIV-1 evades antibody-dependent cellular cytotoxicity (ADCC) responses not only by controlling Env conformation and quantity at the cell surface but also by altering NK cell activation via the downmodulation of several ligands of activating and co-activating NK cell receptors. The signaling lymphocy...

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Detalles Bibliográficos
Autores principales: Marchitto, Lorie, Benlarbi, Mehdi, Prévost, Jérémie, Laumaea, Annemarie, Descôteaux-Dinelle, Jade, Medjahed, Halima, Bourassa, Catherine, Gendron-Lepage, Gabrielle, Kirchhoff, Frank, Sauter, Daniel, Hahn, Beatrice H., Finzi, Andrés, Richard, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470595/
https://www.ncbi.nlm.nih.gov/pubmed/37404017
http://dx.doi.org/10.1128/mbio.00789-23