Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1

DNA methyltransferase 1 (DNMT1) is the enzyme primarily responsible for propagation of the methylation pattern in cells. Mutations in DNMT1 have been linked to the development of adult-onset neurodegenerative disorders; these disease-associated mutations occur in the regulatory replication foci-targ...

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Detalles Bibliográficos
Autores principales: Switzer, Rebecca L., Hartman, Zach J., Hewett, Geoffrey R., Carroll, Clara F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470860/
https://www.ncbi.nlm.nih.gov/pubmed/37663147
http://dx.doi.org/10.3390/dna3030010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470860/
https://www.ncbi.nlm.nih.gov/pubmed/37663147
http://dx.doi.org/10.3390/dna3030010

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