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Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1
DNA methyltransferase 1 (DNMT1) is the enzyme primarily responsible for propagation of the methylation pattern in cells. Mutations in DNMT1 have been linked to the development of adult-onset neurodegenerative disorders; these disease-associated mutations occur in the regulatory replication foci-targ...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470860/ https://www.ncbi.nlm.nih.gov/pubmed/37663147 http://dx.doi.org/10.3390/dna3030010 |