Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

TP73, a member of the p53 family, is expressed as TAp73 and ΔNp73 along with multiple C-terminal isoforms (α−η). ΔNp73 is primarily expressed in neuronal cells and necessary for neuronal development. Interestingly, while TAp73α is a tumor suppressor and predominantly expressed in normal cells, TAp73...

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Detalles Bibliográficos
Autores principales: Kong, Xiangmudong, Yan, Wensheng, Sun, Wenqiang, Zhang, Yanhong, Yang, Hee Jung, Chen, Mingyi, Chen, Hongwu, de Vere White, Ralph W, Zhang, Jin, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471163/
https://www.ncbi.nlm.nih.gov/pubmed/37650871
http://dx.doi.org/10.7554/eLife.82115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471163/
https://www.ncbi.nlm.nih.gov/pubmed/37650871
http://dx.doi.org/10.7554/eLife.82115

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