Persistent hypoxia promotes myofibroblast differentiation via GPR‐81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts

Hypoxia, a state of insufficient oxygen availability, promotes cellular lactate production. Lactate levels are increased in lungs from patients with idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive scar formation, and lactate is implicated in the pathobiology of lung fibrosi...

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Detalles Bibliográficos
Autores principales: Nho, Richard S., Rice, Cami, Prasad, Jayendra, Bone, Hannah, Farkas, Laszlo, Rojas, Mauricio, Horowitz, Jeffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471601/
https://www.ncbi.nlm.nih.gov/pubmed/37653539
http://dx.doi.org/10.14814/phy2.15759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471601/
https://www.ncbi.nlm.nih.gov/pubmed/37653539
http://dx.doi.org/10.14814/phy2.15759

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