Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia

N-methyl-d-aspartate (NMDA) receptor hypofunctionality is a well-studied hypothesis for schizophrenia pathophysiology, and daily dosing of the NMDA receptor co-agonist, d-serine, in clinical trials has shown positive effects in patients. Therefore, inhibition of d-amino acid oxidase (DAAO) has the p...

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Detalles Bibliográficos
Autores principales: Fradley, Rosa, Goetghebeur, Pascal, Miller, David, Burley, Russell, Almond, Sarah, Gruart i Massó, Agnès, Delgado García, José M., Zhu, Bin, Howley, Eimear, Neill, Jo C., Grayson, Ben, Gaskin, Philip, Carlton, Mark, Gray, Ian, Serrats, Jordi, Davies, Ceri H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471729/
https://www.ncbi.nlm.nih.gov/pubmed/37289348
http://dx.doi.org/10.1007/s11064-023-03956-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471729/
https://www.ncbi.nlm.nih.gov/pubmed/37289348
http://dx.doi.org/10.1007/s11064-023-03956-2

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