Metformin does not slow cyst growth in the PCK rat model of polycystic kidney disease

Metformin (MET) has the potential to activate p‐AMPK and block mTORC1‐induced proliferation of tubular cells in PKD kidneys. The aim of this study was to determine the effects of MET on cyst growth, kidney function, AMPK and mTOR signaling, and lactate levels in male PCK rats, a Pkhd1 gene mutation...

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Detalles Bibliográficos
Autores principales: Oto, Ozgur A., Atwood, Daniel J., Chaudhary, Anjana, He, Zhibin, Li, Amy S., Wempe, Michael F., Edelstein, Charles L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471794/
https://www.ncbi.nlm.nih.gov/pubmed/37653564
http://dx.doi.org/10.14814/phy2.15776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471794/
https://www.ncbi.nlm.nih.gov/pubmed/37653564
http://dx.doi.org/10.14814/phy2.15776

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