Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation

Uridine diphosphate glucuronosyltransferases (UGTs) are highly expressed in the liver and are involved in the metabolism of many drugs. In particular, UGT1A1 has a genetic polymorphism that causes decreased activity, leading to drug-induced hepatotoxicity. Therefore, an in vitro evaluation system th...

Descripción completa

Detalles Bibliográficos
Autores principales: Shintani, Tomohiro, Imamura, Chiharu, Ueyama-Toba, Yukiko, Inui, Jumpei, Watanabe, Akira, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471830/
https://www.ncbi.nlm.nih.gov/pubmed/37663646
http://dx.doi.org/10.1016/j.omtm.2023.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471830/
https://www.ncbi.nlm.nih.gov/pubmed/37663646
http://dx.doi.org/10.1016/j.omtm.2023.08.003

Ejemplares similares