T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variants

Pathogenic mitochondrial DNA (mtDNA) single-nucleotide variants are a common cause of adult mitochondrial disease. Levels of some variants decrease with age in blood. Given differing division rates, longevity, and energetic requirements within haematopoietic lineages, we hypothesised that cell-type–...

Descripción completa

Detalles Bibliográficos
Autores principales: Franklin, Imogen G, Milne, Paul, Childs, Jordan, Boggan, Róisín M, Barrow, Isabel, Lawless, Conor, Gorman, Gráinne S, Ng, Yi Shiau, Collin, Matthew, Russell, Oliver M, Pickett, Sarah J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471888/
https://www.ncbi.nlm.nih.gov/pubmed/37652671
http://dx.doi.org/10.26508/lsa.202302271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471888/
https://www.ncbi.nlm.nih.gov/pubmed/37652671
http://dx.doi.org/10.26508/lsa.202302271

Ejemplares similares