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T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variants

Pathogenic mitochondrial DNA (mtDNA) single-nucleotide variants are a common cause of adult mitochondrial disease. Levels of some variants decrease with age in blood. Given differing division rates, longevity, and energetic requirements within haematopoietic lineages, we hypothesised that cell-type–...

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Detalles Bibliográficos
Autores principales:	Franklin, Imogen G, Milne, Paul, Childs, Jordan, Boggan, Róisín M, Barrow, Isabel, Lawless, Conor, Gorman, Gráinne S, Ng, Yi Shiau, Collin, Matthew, Russell, Oliver M, Pickett, Sarah J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471888/ https://www.ncbi.nlm.nih.gov/pubmed/37652671 http://dx.doi.org/10.26508/lsa.202302271

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