Activated protein C modulates T-cell metabolism and epigenetic FOXP3 induction via α-ketoglutarate

A direct regulation of adaptive immunity by the coagulation protease activated protein C (aPC) has recently been established. Preincubation of T cells with aPC for 1 hour before transplantation increases FOXP3(+) regulatory T cells (Tregs) and reduces acute graft-versus-host disease (aGVHD) in mice,...

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Detalles Bibliográficos
Autores principales: Gupta, Dheerendra, Elwakiel, Ahmed, Ranjan, Satish, Pandey, Manish Kumar, Krishnan, Shruthi, Ambreen, Saira, Henschler, Reinhard, Rana, Rajiv, Keller, Maria, Ceglarek, Uta, Shahzad, Khurrum, Kohli, Shrey, Isermann, Berend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471940/
https://www.ncbi.nlm.nih.gov/pubmed/37315174
http://dx.doi.org/10.1182/bloodadvances.2023010083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471940/
https://www.ncbi.nlm.nih.gov/pubmed/37315174
http://dx.doi.org/10.1182/bloodadvances.2023010083

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