Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene

Introduction: ß-chloroprene (2-chloro-1,3-butadiene; CP) causes lung tumors after inhalation exposures in rats and mice. Mice develop these tumors at lower exposures than rats. In rats CP exposures cause depletion of lung glutathione (GSH). Methods: PBPK models developed to relate the appearance of...

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Detalles Bibliográficos
Autores principales: Campbell, J. L., Clewell, H. J., Van Landingham, C., Gentry, P. R., Andersen, M. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472072/
https://www.ncbi.nlm.nih.gov/pubmed/37663267
http://dx.doi.org/10.3389/fphar.2023.1223808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472072/
https://www.ncbi.nlm.nih.gov/pubmed/37663267
http://dx.doi.org/10.3389/fphar.2023.1223808

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