Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM Complex

The androgen receptor (AR) pathway regulates key cell survival programs in prostate epithelium. The AR represents a near-universal driver and therapeutic vulnerability in metastatic prostate cancer, and targeting AR has a remarkable therapeutic index. Though most approaches directed toward AR focus...

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Detalles Bibliográficos
Autores principales: Nyquist, Michael D., Coleman, Ilsa M., Lucas, Jared M., Li, Dapei, Hanratty, Brian, Meade, Hannah, Mostaghel, Elahe A., Plymate, Stephen R., Corey, Eva, Haffner, Michael C., Nelson, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472100/
https://www.ncbi.nlm.nih.gov/pubmed/37352376
http://dx.doi.org/10.1158/0008-5472.CAN-22-2613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472100/
https://www.ncbi.nlm.nih.gov/pubmed/37352376
http://dx.doi.org/10.1158/0008-5472.CAN-22-2613

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