Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors

Adoptive T-cell therapy aims to achieve lasting tumor clearance, requiring enhanced engraftment and survival of the immune cells. Cytokines are paramount modulators of T-cell survival and proliferation. Cytokine receptors signal via ligand-induced dimerization, and this principle has been hijacked u...

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Detalles Bibliográficos
Autores principales: Righi, Matteo, Gannon, Isaac, Robson, Matthew, Srivastava, Saket, Kokalaki, Evangelia, Grothier, Thomas, Nannini, Francesco, Allen, Christopher, Bai, Yuchen V., Sillibourne, James, Cordoba, Shaun, Thomas, Simon, Pule, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472109/
https://www.ncbi.nlm.nih.gov/pubmed/37352396
http://dx.doi.org/10.1158/2326-6066.CIR-22-0640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472109/
https://www.ncbi.nlm.nih.gov/pubmed/37352396
http://dx.doi.org/10.1158/2326-6066.CIR-22-0640

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