Transcriptional kinetic synergy: A complex landscape revealed by integrating modeling and synthetic biology

Transcription factors (TFs) control gene expression, often acting synergistically. Classical thermodynamic models offer a biophysical explanation for synergy based on binding cooperativity and regulated recruitment of RNA polymerase. Because transcription requires polymerase to transition through mu...

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Detalles Bibliográficos
Autores principales: Martinez-Corral, Rosa, Park, Minhee, Biette, Kelly M., Friedrich, Dhana, Scholes, Clarissa, Khalil, Ahmad S., Gunawardena, Jeremy, DePace, Angela H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472254/
https://www.ncbi.nlm.nih.gov/pubmed/37080164
http://dx.doi.org/10.1016/j.cels.2023.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472254/
https://www.ncbi.nlm.nih.gov/pubmed/37080164
http://dx.doi.org/10.1016/j.cels.2023.02.003

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