Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

DNA-dependent protein kinase (DNA-PK), a driver of the non-homologous end-joining (NHEJ) DNA damage response pathway, plays an instrumental role in repairing double-strand breaks (DSB) induced by DNA-damaging poisons. We evaluate ZL-2201, an orally bioavailable, highly potent, and selective pharmaco...

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Detalles Bibliográficos
Autores principales: Lal, Shruti, Bhola, Neil E., Sun, Bee-Chun, Chen, Yuping, Huang, Tom, Morton, Vivian, Chen, Kevin X., Xia, Shanghua, Zhang, Haoyu, Parikh, Nehal S., Ye, Qiuping, Veiby, O. Petter, Bellovin, David I., Ji, Yuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473160/
https://www.ncbi.nlm.nih.gov/pubmed/37663435
http://dx.doi.org/10.1158/2767-9764.CRC-23-0304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473160/
https://www.ncbi.nlm.nih.gov/pubmed/37663435
http://dx.doi.org/10.1158/2767-9764.CRC-23-0304

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