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Brief excitotoxic insults cause a calpain-mediated increase in nuclear membrane permeability in neonatal neurons
Neuronal edema after excitotoxic brain insults results in neuronal injury and death. Osmotic and surgical interventions designed to mitigate edema yield poor clinical outcomes, highlighting the need to explore other mechanisms. Concurrent with neuronal swelling, excessive Ca(2+) loading can be delet...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473591/ https://www.ncbi.nlm.nih.gov/pubmed/37662276 http://dx.doi.org/10.1101/2023.08.22.554167 |