C5aR1 antagonism suppresses inflammatory glial gene expression and alters cellular signaling in an aggressive Alzheimer’s model

Alzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. Pharmacologic inhibition of C5aR1 reduces plaque load, gliosis and memory deficits in animal models. However, the cellular basis underlying this neuro...

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Detalles Bibliográficos
Autores principales: Schartz, Nicole D., Liang, Heidi Y., Carvalho, Klebea, Chu, Shu-Hui, Mendoza-Arvilla, Adrian, Petrisko, Tiffany J., Gomez-Arboledas, Angela, Mortazavi, Ali, Tenner, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473603/
https://www.ncbi.nlm.nih.gov/pubmed/37662399
http://dx.doi.org/10.1101/2023.08.22.554306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473603/
https://www.ncbi.nlm.nih.gov/pubmed/37662399
http://dx.doi.org/10.1101/2023.08.22.554306

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