Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β-cell autoimmunity. We investigated how CVB impacts human β cells and anti-CVB T-cell responses. β cells were efficiently infected by CVB in vitro, downregulated HLA Class I and presented few, selected HLA-bound viral peptide...

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Detalles Bibliográficos
Autores principales: Vecchio, Federica, Carré, Alexia, Korenkov, Daniil, Zhou, Zhicheng, Apaolaza, Paola, Tuomela, Soile, Burgos-Morales, Orlando, Snowhite, Isaac, Perez-Hernandez, Javier, Brandao, Barbara, Afonso, Georgia, Halliez, Clémentine, Kaddis, John, Kent, Sally C., Nakayama, Maki, Richardson, Sarah J., Vinh, Joelle, Verdier, Yann, Laiho, Jutta, Scharfmann, Raphael, Solimena, Michele, Marinicova, Zuzana, Bismuth, Elise, Lucidarme, Nadine, Sanchez, Janine, Bustamante, Carmen, Gomez, Patricia, Buus, Soren, You, Sylvaine, Pugliese, Alberto, Hyoty, Heikki, Rodriguez-Calvo, Teresa, Flodstrom-Tullberg, Malin, Mallone, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473604/
https://www.ncbi.nlm.nih.gov/pubmed/37662376
http://dx.doi.org/10.1101/2023.08.19.553954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473604/
https://www.ncbi.nlm.nih.gov/pubmed/37662376
http://dx.doi.org/10.1101/2023.08.19.553954

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