3D modeling of CpG DNA binding with matrix lumican shows leucine-rich repeat motif involvement as in TLR9-CpG DNA interactions

Lumican is an extracellular matrix proteoglycan, known to regulate toll-like receptor (TLR) signaling in innate immune cells. In experimental settings, lumican suppresses TLR9 signaling by binding to, and sequestering its synthetic ligand, CpG-DNA, in non-signal permissive endosomes. However, the mo...

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Detalles Bibliográficos
Autores principales: Choi, Tansol, Maiti, George, Chakravarti, Shukti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473624/
https://www.ncbi.nlm.nih.gov/pubmed/37662233
http://dx.doi.org/10.1101/2023.08.21.554201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473624/
https://www.ncbi.nlm.nih.gov/pubmed/37662233
http://dx.doi.org/10.1101/2023.08.21.554201

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