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3D modeling of CpG DNA binding with matrix lumican shows leucine-rich repeat motif involvement as in TLR9-CpG DNA interactions
Lumican is an extracellular matrix proteoglycan, known to regulate toll-like receptor (TLR) signaling in innate immune cells. In experimental settings, lumican suppresses TLR9 signaling by binding to, and sequestering its synthetic ligand, CpG-DNA, in non-signal permissive endosomes. However, the mo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473624/ https://www.ncbi.nlm.nih.gov/pubmed/37662233 http://dx.doi.org/10.1101/2023.08.21.554201 |