Crystallographic and thermodynamic evidence of negative cooperativity of flavin and tryptophan binding in the flavin-dependent halogenases AbeH and BorH

The flavin-dependent halogenase AbeH produces 5-chlorotryptophan in the biosynthetic pathway of the chlorinated bisindole alkaloid BE-54017. We report that in vitro, AbeH (assisted by the flavin reductase AbeF) can chlorinate and brominate tryptophan as well as other indole derivatives and substrate...

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Detalles Bibliográficos
Autores principales: Ashaduzzaman, Md, Lingkon, Kazi, De Silva, Aravinda J., Bellizzi, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473636/
https://www.ncbi.nlm.nih.gov/pubmed/37662313
http://dx.doi.org/10.1101/2023.08.22.554356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473636/
https://www.ncbi.nlm.nih.gov/pubmed/37662313
http://dx.doi.org/10.1101/2023.08.22.554356

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