A parametrized two-domain thermodynamic model explains diverse mutational effects on protein allostery

New experimental findings continue to challenge our understanding of protein allostery. Recent deep mutational scanning study showed that allosteric hotspots in the tetracycline repressor (TetR) and its homologous transcriptional factors are broadly distributed rather than spanning well-defined stru...

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Detalles Bibliográficos
Autores principales: Liu, Zhuang, Gillis, Thomas, Raman, Srivatsan, Cui, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473640/
https://www.ncbi.nlm.nih.gov/pubmed/37662419
http://dx.doi.org/10.1101/2023.08.06.552196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473640/
https://www.ncbi.nlm.nih.gov/pubmed/37662419
http://dx.doi.org/10.1101/2023.08.06.552196

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