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A parametrized two-domain thermodynamic model explains diverse mutational effects on protein allostery
New experimental findings continue to challenge our understanding of protein allostery. Recent deep mutational scanning study showed that allosteric hotspots in the tetracycline repressor (TetR) and its homologous transcriptional factors are broadly distributed rather than spanning well-defined stru...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473640/ https://www.ncbi.nlm.nih.gov/pubmed/37662419 http://dx.doi.org/10.1101/2023.08.06.552196 |